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KMID : 0043319980210040481
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Archives of Pharmacal Research
1998 Volume.21 No. 4 p.481 ~ p.484
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Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages
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Ryu Jae-Ha
Lee Hwa-Jin
Jeong Yeon-Su
Ryu Shi-Yong
Han Yong-Nam
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Abstract
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In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
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KEYWORD
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Yomogin, Artemisia princeps, Nitric oxide, Nitric oxide synthase, Induction, LPS, Inhibitor
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